Published in

American Chemical Society, Nano Letters, 3(6), p. 496-500, 2006

DOI: 10.1021/nl052492p

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Single Molecule Nanometronome

Journal article published in 2006 by Chittanon Buranachai, Sean A. McKinney, Taekjip Ha ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

We constructed a DNA-based nano-mechanical device called the nano-metronome. Our device is made by introducing complementary single stranded overhangs at the two arms of the DNA four-way junction. The ticking rates of this stochastic metronome depend on ion concentrations and can be changed by a set of DNA-based switches to deactivate/reactivate the sticky end. Since the device displays clearly distinguishable responses even with a single basepair difference, it may lead to a single molecule sensor of minute sequence differences of a target DNA.