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PeerJ, PeerJ, (2), p. e461, 2014

DOI: 10.7717/peerj.461

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Characterisation of the interaction of neuropilin-1 with heparin and a heparan sulfate mimetic library of heparin-derived sugars

This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Background. Neuropilin-1 (NRP-1) is a multidomain membrane protein with soluble isoforms interacting with a complex network of other membrane receptors, their respective ligands and heparan sulfate (HS). It is involved in the development of vasculature, neural patterning, immunological responses and pathological angiogenesis.