Published in
Hindawi, BioMed Research International, (2014), p. 1-10, 2014
DOI: 10.1155/2014/453972
Links
- ORCID
- Hindawi | PDF
- ORCID
- [www.ncbi.nlm.nih.gov] | PDF
- [doaj.org] | PDF
- [doaj.org] | PDF
- [www.researchgate.net]
- [www.ncbi.nlm.nih.gov] | PDF
Tools
Anticancer Activities of Citrus Peel Polymethoxyflavones Related to Angiogenesis and Others
,
Jinhan Wang ,
Lianying Fang,
Zuliang Zheng,
Dexian Zhi,
Suying Wang,
Shiming Li,
Chi-Tang Ho,
Hui Zhao
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Abstract
Citrus is a kind of common fruit and contains multiple beneficial nutrients for human beings. Flavonoids, as a class of plant secondary metabolites, exist in citrus fruits abundantly. Due to their broad range of pharmacological properties, citrus flavonoids have gained increased attention. Accumulative in vitro and in vivo studies indicate protective effects of polymethoxyflavones (PMFs) against the occurrence of cancer. PMFs inhibit carcinogenesis by mechanisms like blocking the metastasis cascade, inhibition of cancer cell mobility in circulatory systems, proapoptosis, and antiangiogenesis. This review systematically summarized anticarcinogenic effect of citrus flavonoids in cancer therapy, together with the underlying important molecular mechanisms, in purpose of further exploring more effective use of citrus peel flavonoids.