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Hindawi, BioMed Research International, (2014), p. 1-10, 2014

DOI: 10.1155/2014/453972

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Anticancer Activities of Citrus Peel Polymethoxyflavones Related to Angiogenesis and Others

Journal article published in 2014 by Liwen Wang ORCID, Jinhan Wang ORCID, Lianying Fang, Zuliang Zheng, Dexian Zhi, Suying Wang, Shiming Li, Chi-Tang Ho, Hui Zhao
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Citrus is a kind of common fruit and contains multiple beneficial nutrients for human beings. Flavonoids, as a class of plant secondary metabolites, exist in citrus fruits abundantly. Due to their broad range of pharmacological properties, citrus flavonoids have gained increased attention. Accumulative in vitro and in vivo studies indicate protective effects of polymethoxyflavones (PMFs) against the occurrence of cancer. PMFs inhibit carcinogenesis by mechanisms like blocking the metastasis cascade, inhibition of cancer cell mobility in circulatory systems, proapoptosis, and antiangiogenesis. This review systematically summarized anticarcinogenic effect of citrus flavonoids in cancer therapy, together with the underlying important molecular mechanisms, in purpose of further exploring more effective use of citrus peel flavonoids.