Published in
Elsevier, Oral Oncology, (66), p. 93-99
DOI: 10.1016/j.oraloncology.2017.01.004
Links
Tools
Salivary gland pleomorphic adenoma in the Netherlands: A nationwide observational study of primary tumor incidence, malignant transformation, recurrence, and risk factors for recurrence
,
E. C. van den Broek,
E. C. (Esther) van den Broek,
M. M. (Martijn M.) Stuiver,
B. A. C. van Dijk,
M. L. F. van Velthuysen ,
B. A. C. (Boukje) van Dijk,
M. L. (M.) van Velthuysen,
A. J. M. (Alfons) Balm,
L. E. Smeele
Full text: Download
Abstract
Introduction Whereas salivary gland pleomorphic adenoma (SGPA) is the most common type of salivary gland tumor, little is known about its epidemiology because national cancer registries do not register this disease. Objectives To establish SGPA incidence trends, rates of secondary malignant transformation and recurrence and associated factors in the Netherlands. Materials and methods Data on incidence, epidemiology, secondary malignant transformation and recurrence were retrieved from the Dutch pathology registry (PALGA) for the years 1992, 1997, 2002, 2007, and 2012. Multivariate analysis was performed to discover the risk factors for recurrence. Results 3506 cases of SGPA were recorded implying an overall European standardized rate of 4.2–4.9 per 100,000 person-years. Our figures showed a female preponderance (1:1.43) with an annual 1% rise in female incidence (95% confidence interval [CI]: 0.2–1.8) and a bimodal age distribution in women (p