In recent years there is a growing interest in the use of emerging advanced technologies in supporting well-being and health promotion. Although few existing programs employ innovative technologies to foster social and emotional learning in adolescence, they do not specifically focus on emotion regulation skills. Further, research in this domain has primarily tested the efficacy of these trainings with one type of measurement technique at a time, although most recent theories highlight that emotions are multi-dimensional and multi-component processes. With the above in mind and to overcome these limitations, we developed a technology-enhanced protocol for the enhancement of emotion regulation, based on evidenced based program, the Building Emotion and Affect Regulation, age-adjusted and combined with virtual characters and wearable physiological sensors. The objective of this paper is to present an overview of the design and development process of this innovative protocol: EmoRegulators