Dissemin is shutting down on January 1st, 2025

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American Society for Microbiology, Journal of Virology, 3(87), p. 1893-1898, 2013

DOI: 10.1128/jvi.02061-12

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Amino Acid Exchanges in the Putative Nuclear Export Signal of Adenovirus Type 5 L4-100K Severely Reduce Viral Progeny due to Effects on Hexon Biogenesis

Journal article published in 2012 by Orkide O. Koyuncu, Thomas Speiseder, Thomas Dobner, Melanie Schmid, Melanie Tramontano ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT The adenovirus type 5 nonstructural L4-100K protein is indispensable for efficient lytic infection. During the late phase, L4-100K promotes selective translation of viral late transcripts and mediates the trimerization of the major capsid protein hexon. In the present study, the role of a potential nuclear export signal in L4-100K was investigated. Intriguingly, amino acid substitutions in this sequence resulted in severely diminished progeny virus production, seemingly by precluding proper hexon biogenesis.