A copper-benzotriazole-based coordination polymer catalyzes the efficient one-pot synthesis of (N’-substituted)-hydrazo-4-aryl-1,4-dihydropyridines from azines
Journal article published in 2016 by
Michael Kallitsakis,
Edward Loukopoulos,
Alaa Abdul-Sada,
Graham J. Tizzard,
Simon J. Coles,
George E. Kostakis 
,
Ioannis N. Lykakis
,
Ioannis N. Lykakis
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Abstract
A series of new (N’-substituted)-hydrazo-4-aryl1,4-dihydropyridines was successfully synthesized via a facile one-pot catalytic pathway utilizing azines and propiolate esters as starting materials and a one-dimensional copper benzotriazole-based coordination polymer as catalyst. In the absence of catalyst, the corresponding 5-substituted 4,5-dihydropyrazoles were formed in moderate to high yields. Finetuning of the catalysts allowed us to gain more insights regarding the plausible reaction mechanism.