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Impact Journals, Oncotarget, 11(8), p. 18010-18020, 2017

DOI: 10.18632/oncotarget.14931

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Akt/mTOR mediated induction of bystander effect signaling in a nucleus independent manner in irradiated human lung adenocarcinoma epithelial cells

Journal article published in 2017 by Lu Li, Lu Wang, Kevin M. Prise ORCID, K. N . Yu ORCID, Guodong Chen, Lianyun Chen, Yide Mei, Wei Han
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Cytoplasm is an important target for the radiation-induced bystander effect (RIBE). In the present work, the critical role of protein kinase B (Akt)/mammalian target of rapamycin (mTOR) pathway in the generation of RIBE signaling after X-ray irradiation and the rapid phosphorylation of Akt and mTOR was observed in the cytoplasm of irradiated human lung adenocarcinoma epithelial (A549) cells. Targeting A549 cytoplasts with individual protons from a microbeam showed that RIBE signal(s) mediated by the Akt/mTOR pathway were generated even in the absence of a cell nucleus. These results provide a new insight into the mechanisms driving the cytoplasmic response to irradiation and their impact on the production of RIBE signal(s).