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Oxford University Press (OUP), Clinical Infectious Diseases, 3(47), p. 421-424

DOI: 10.1086/589867

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Detection of Nonnucleoside Reverse-Transcriptase Inhibitor–Resistant HIV-1 after Discontinuation of Virologically Suppressive Antiretroviral Therapy

Journal article published in 2008 by C. Bradley Hare, C. Bradley Bradley Hare, John Mellors, Amy Krambrink, Zhaohui Su, Daniel Skiest, David M. Margolis ORCID, Sheran Sheran S Patel, Douglas Barnas, Lisa Frenkel, Robert W. Coombs, Francesca Aweeka, Gene D. Morse, David W. Haas, Valerie Boltz and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Using standard and ultrasensitive techniques, we detected nonnucleoside reverse-transcriptase inhibitor–associated resistance mutations in 11 (20%) of 54 subjects who discontinued virologically suppressive nonnucleoside reverse-transcriptase inhibitor–containing antiretroviral therapy. Resistance was detected in 45% and 14% of subjects with a baseline human immunodeficiency virus type 1 RNA level of 51–400 copies/mL and ≤50 copies/mL, respectively. Mutations remained detectable for at least 48 weeks in some subjects.