We report evidence for the electrochemical performances of two Li-ion full cells, built up by the combination of LiCo2/3Ni1/6Mn1/6O2 cathode material with MnSn2 intermetallic and Li4Ti5O12 spinel as the anode materials, respectively. MnSn2 and Li4Ti5O12 electrode materials illustrate different working voltage versus the redox couple Li+/Li0 and different reactionmechanisms during lithiuminsertion/deinsertion cycles. The structure,morphological characteristics and the electrochemical properties of the studied materialswere investigated by X-ray diffraction (XRD), scanning electron microscopy (SEM) and electrochemical techniques. The two full-cell configurations showed different electrochemical behaviors. The MnSn2//LiCo2/3Ni1/6Mn1/6O2 configuration exhibits high working voltage (~3.5 V) and specific capacity (~200 mAh/gcathode) but suffers from high irreversible capacity loss during the first cycles and capacity fading during cycling. The Li4Ti5O12//LiCo2/3Ni1/6Mn1/6O2 cell demonstrated excellent cycling properties at different C-rates with 100% capacity retention after 150 cycles at 1 C. Although the working voltage (~2.2 V) and the specific capacity (~140 mAh/gcathode) are lower than those of the MnSn2//LiCo2/3Ni1/6Mn1/6O2 configuration, the other measured electrochemical properties suggest that the Li4Ti5O12//LiCo2/3Ni1/6Mn1/6O2 full cell is a potential candidate for battery application due to its excellent cycling performance and improved safety. ; Peer reviewed