Published in
Public Library of Science, PLoS ONE, 1(12), p. e0169836, 2017
DOI: 10.1371/journal.pone.0169836
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Narcolepsy Type 1 Is Associated with a Systemic Increase and Activation of Regulatory T Cells and with a Systemic Activation of Global T Cells
Journal article published in 2017 by
Michel Lecendreux,
Guillaume Churlaud 
,
Fabien Pitoiset,
Tu Anh Tran,
Armelle Regnault,
Tran Ta,
Roland Liblau ,
David Klatzmann ,
Michelle Rosenzwajg
,
Fabien Pitoiset,
Tu Anh Tran,
Armelle Regnault,
Tran Ta,
Roland Liblau ,
David Klatzmann ,
Michelle Rosenzwajg
This paper is made freely available by the publisher.
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Abstract
Narcolepsy is a rare neurologic disorder characterized by excessive daytime sleepiness, cataplexy and disturbed nocturnal sleep patterns. Narcolepsy type 1 (NT1) has been shown to result from a selective loss of hypothalamic hypocretin-secreting neurons with patients typically showing low CSF-hypocretin levels (