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Oxford University Press (OUP), Nucleic Acids Research, D1(45), p. D555-D559

DOI: 10.1093/nar/gkw960

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The antiSMASH database, a comprehensive database of microbial secondary metabolite biosynthetic gene clusters

Journal article published in 2016 by Kai Blin ORCID, Marnix H. Medema, Renzo Kottmann, Sang Yup Lee, Tilmann Weber ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Secondary metabolites produced by microorganisms are the main source of bioactive compounds that are in use as antimicrobial and anticancer drugs, fungicides, herbicides and pesticides. In the last decade, the increasing availability of microbial genomes has established genome mining as a very important method for the identification of their biosynthetic gene clusters (BGCs). One of the most popular tools for this task is antiSMASH. However, so far, antiSMASH is limited to de novo computing results for user-submitted genomes and only partially connects these with BGCs from other organisms. Therefore, we developed the antiSMASH database, a simple but highly useful new resource to browse antiSMASH-annotated BGCs in the currently 3907 bacterial genomes in the database and perform advanced search queries combining multiple search criteria. antiSMASH-DB is available at http://antismash-db.secondarymetabolites.org/.