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Springer (part of Springer Nature), Archives of Virology, 11(161), p. 3263-3268

DOI: 10.1007/s00705-016-3016-3

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IFN-stimulated gene expression is independent of the IFNL4 genotype in chronic HIV-1 infection

Journal article published in 2016 by Katia Monteleone, Giuseppe Corano Scheri, Maura Statzu, Carla Selvaggi, Francesca Falasca, Gabriella d’Ettorre, Noemi Giustini, Ivano Mezzaroma, Ombretta Turriziani, Guido Antonelli ORCID, Carolina Scagnolari ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

This study aimed to evaluate the association between the IFNL4 rs368234815 (ΔG/TT) dinucleotide polymorphism and the IFN response during chronic HIV-1 infection. We carried out genotyping analysis and measured the expression of IFN-stimulated genes (ISGs) (myxovirus resistance protein A [MxA], ISG15, ISG56, apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like [APOBEC] 3F and APOBEC3G) on peripheral blood mononuclear cells collected from naïve and HAART-treated HIV-1-infected patients. There were no statistically significant differences in endogenous ISGs mRNA levels among HIV-1-positive patients bearing different IFNL4 genotypes, suggesting that ISG expression is independent of the IFNL4 genotype in HIV-1 infection