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Oxford University Press (OUP), Clinical Infectious Diseases, 7(64), p. 939-946

DOI: 10.1093/cid/cix003

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High frequency of blackwater fever among children presenting to hospital with severe febrile illnesses in Eastern Uganda

Journal article published in 2017 by Peter Olupot-Olupot, Ce Engoru, Sophie Uyoga ORCID, Rita Muhindo, Alex Macharia, Sarah Kiguli, Ro Opoka, Samuel Akech, Carolyne Ndila, Richard Nyeko, George Mtove, Julius Nteziyaremye, Martin Chebet, Ec George, Ag Babiker and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Background In the Fluid-Expansion-as-a-Supportive-Treatment (FEAST) trial an unexpectedly-high proportion of participants from Eastern Uganda presented with blackwater fever (BWF). Methods We describe the prevalence and outcome of BWF among trial participants and compare the prevalence of three malaria-protective red blood cell polymorphisms in BWF-cases versus both trial (non-BWF) and population-controls. Findings Of 3,170 trial participants 394 (12.4%) had BWF. The majority (318; 81.0%) presented in Eastern Uganda: the subjects of further analysis. BWF cases typically presented with both clinical jaundice 254/318 (80%) and severe-anaemia (Hb