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Data File S13. Genetic interaction enrichment among protein complexes

This paper is available in a repository.
This paper is available in a repository.

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Abstract

This file indicates fold enrichment and biases in positive vs. negative interaction frequency for protein complexes and is described in detail above (see ìAnalysis of protein complexes exhibiting a positive interaction enrichment biasî). Rows highlighted in yellow indicate protein complexes that show > 1.5X enrichment for positive interactions (ìE_fold_pos) stronger enrichment for positive versus negative interactions when screened against the essential TSA. The file consists of the following columns: (A) Protein complex name (B) Number of complex member-encoding query genes screened against the DMA (ìqueries_vs_DMAî). (C) Number of complex member-encoding query genes screened against the TSA (ìqueries_vs_TSAî). (D) Nonessential-negative GI fold enrichment (ìN_fold_negî): negative interaction fold enrichment for a complex of interest with nonessential genes not in the complex. (E) Essential-negative GI fold enrichment (ìE_fold_negî): negative interaction fold enrichment for a complex of interest with essential genes not in the complex. (F) Nonessential-positive GI fold enrichment (ìN_fold_posî): positive interaction fold enrichment for a complex of interest with nonessential genes not in the complex. (G) Essential-positive GI fold enrichment (ìE_fold_posî): positive interaction fold enrichment for a complex of interest with essential genes not in the complex. Complexes with a positive GI enrichment > 1.5X are highlighted in yellow. These values were used to generate Fig. 8C. (H) Positive GI bias with essential genes (ìposGI_bias_with_Eî): the relative positive:negative enrichment ratio of essential to nonessential genes for the complex of interest (calculated as [D/E]/[F/G]). Complexes with a positive GI enrichment > 1 and a positive GI bias > 1.5 are highlighted in yellow. These values were used to generate Fig. 8D. (I) Positive GI bias with nonessential genes (posGI_bias_with_Nî): the relative positive:negative enrichment ratio of nonessential to essential genes for the complex of interest (calculated as [F/G]/[D/E]).