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Elsevier, Radiotherapy & Oncology, 3(120), p. 434-440

DOI: 10.1016/j.radonc.2016.03.020

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Image guided adaptive brachytherapy with combined intracavitary and interstitial technique improves the therapeutic ratio in locally advanced cervical cancer: Analysis from the retroEMBRACE study

Journal article published in 2016 by Lars Fokdal ORCID, Fokdal Lu, Alina Sturdza, Renaud Mazeron, Christine Haie-Meder ORCID, Li Tee Tan, Charles Gillham, Barbara Šegedin, Ina Jürgenliemk-Schultz, Christian Kirisits, Peter Hoskin, Richard Pötter, Jacob C. Lindegaard, Kari Tanderup ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Background and purpose Image guided adaptive brachytherapy (IGABT) using intracavitary applicators (IC) has led to a significant improvement of local control in locally advanced cervical cancer (LACC). Further improvement has been obtained with combined intracavitary/interstitial (IC/IS) applicators. The aim of this analysis was to evaluate the impact on local control and late morbidity of application of combined IS/IC brachytherapy in a large multicentre population. Material/methods 610 patients with LACC from the retroEMBRACE study were included. Patients were divided into an IC group (N = 310) and an IC/IS group (N = 300). The IC/IS group was defined from the time point, when a centre performed IC/IS brachytherapy in more than 20% of cases. Results With systematic usage of IC/IS the D90 of CTVHR increased from 83 ± 14 Gy to 92 ± 13 Gy (p