This article addresses the various properties and different methods of estimation of the unknown parameters of the Transmuted Rayleigh (TR) distribution from the frequentist point of view. Although, our main focus is on estimation from frequentist point of view, yet, various mathematical and statistical properties of the TR distribution (such as quantiles, moments, moment generating function, conditional moments, hazard rate, mean residual lifetime, mean past lifetime, mean deviation about mean and median, the stochastic ordering, various entropies, stress-strength parameter and order statistics) are derived. We briefly describe different frequentist methods of estimation approaches, namely, maximum likelihood estimators, moments estimators, L-moment estimators, percentile based estimators, least squares estimators, method of maximum product of spacings, method of Cramér-von-Mises, methods of Anderson-Darling and right-tail Anderson-Darling and compare them using extensive numerical simulations. Monte Carlo simulations are performed to compare the performances of the proposed methods of estimation for both small and large samples. Finally, the potentiality of the model is analyzed by means of two real data sets which is further illustrated by obtaining bias and standard error of the estimates and the bootstrap percentile confidence intervals using bootstrap resampling.