The paper deals with the potential of high energy-efficient windows with granular silica aerogel for energy saving in building refurbishment. Different glazing systems were investigated considering two kinds of granular silica aerogel and different glass layers. Thermal transmittance and optical properties of the samples were measured and used in building simulations. The aerogel impact on heat transfer is remarkable, allowing a thermal transmittance of 1.0–1.1 W/(m2·K) with granular aerogel in interspace only 15 mm in thickness. A 63% reduction in U-value was achieved when compared to the corresponding conventional windows, together with a significant reduction (30%) in light transmittance. When assembled with a low-e glass, the U-value reduction was lower (31%), but a moderate reduction in light transmittance (about 10%) was observed for larger granules. Energy simulations for a case study in different climate conditions (hot, moderate, and cold) showed a reduction in energy demand both for heating and cooling for silica aerogel glazing systems, when compared to the conventional ones. The new glazings are a suitable solution for building refurbishment, thanks to low U-values and total solar transmittance, also in warm climate conditions.