NASA's Orbiting Carbon Observatory-2 (OCO-2) has been measuring carbon dioxide column-averaged dry air mole fractions, XCO2, in the Earth’s atmosphere for almost two years. In this paper, we describe the comparisons between the OCO-2 version 7Br retrievals and XCO2 estimates from OCO-2's primary ground-based validation network: the Total Carbon Column Observing Network (TCCON). The OCO-2 XCO2 retrievals, after bias correction, agree well globally with the TCCON for nadir, glint, and target observations, with median differences less than 0.5 ppm and RMS differences typically below 1.5 ppm. Target observations over TCCON stations correlate best with the TCCON data (R2 = 0.83) on a global scale. At local scales, the target comparisons reveal residual biases likely related to surface properties and aerosol scattering. It is thus crucial to continue measurement comparisons with TCCON to monitor and evaluate the OCO-2 XCO2 data quality throughout its mission.