Dissemin is shutting down on January 1st, 2025

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Medknow Publications, Neural Regeneration Research, 12(11), p. 1884, 2016

DOI: 10.4103/1673-5374.197079

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Targeting cell surface receptors for axon regeneration in the central nervous system

Journal article published in 2016 by Melissa R. Andrews ORCID, Menghon Cheah
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Axon regeneration in the CNS is largely unsuccessful due to excess inhibitory extrinsic factors within lesion sites together with an intrinsic inability of neurons to regrow following injury. Recent work demonstrates that forced expression of certain neuronal transmembrane receptors can recapitulate neuronal growth resulting in successful growth within and through inhibitory lesion environments. More specifically, neuronal expression of integrin receptors such as alpha9beta1 integrin which binds the extracellular matrix glycoprotein tenascin-C, trk receptors such as trkB which binds the neurotrophic factor BDNF, and receptor PTPσ which binds chondroitin sulphate proteoglycans, have all been show to significantly enhance regeneration of injured axons. We discuss how reintroduction of these receptors in damaged neurons facilitates signalling from the internal environment of the cell with the external environment of the lesion milieu, effectively resulting in growth and repair following injury. In summary, we suggest an appropriate balance of intrinsic and extrinsic factors are required to obtain substantial axon regeneration. ; Publisher PDF ; Peer reviewed