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SAGE Publications, Journal of Cerebral Blood Flow and Metabolism, 3(37), p. 755-761, 2017

DOI: 10.1177/0271678x16684141

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Lickometry: A novel and sensitive method for assessing functional deficits in rats after stroke

Journal article published in 2016 by Jewel Ahmed, Dominic M. Dwyer, Tracy D. Farr ORCID, David J. Harrison, Stephen B. Dunnett, Rebecca C. Trueman ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The need for sensitive, easy to administer assessments of long-term functional deficits is crucial in pre-clinical stroke research. In the present study, we introduce lickometry (lick microstructure analysis) as a precise method to assess sensorimotor deficits up to 40 days after middle cerebral artery occlusion in rats. Impairments in drinking efficiency compared to controls, and a compensatory increase in the number of drinking clusters were observed. This highlights the utility of this easy to administer task in assessing subtle, long-term deficits, which could be likened to oral deficits in patients.