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Oxford University Press (OUP), Rheumatology, p. kew413

DOI: 10.1093/rheumatology/kew413

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The incidence, prevalence and mortality of granulomatosis with polyangiitis in the UK Clinical Practice Research Datalink

Journal article published in 2016 by Fiona A. Pearce, Matthew J. Grainge, Peter C. Lanyon ORCID, Richard A. Watts, Richard B. Hubbard
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Objectives: To estimate the incidence, prevalence and mortality of Granulomatosis with polyangiitis (GPA) in the United Kingdom. Methods: We conducted a historical cohort study using data from the Clinical Practice Research Datalink and Hospital Episode Statistics (CPRD-HES). We calculated incidence rate ratios, adjusted for age, gender and ethnicity, using Poisson regression. Results: We identified 462 cases diagnosed between 1997 and 2013. Our overall estimate of incidence was 11.8 (95% CI 10.7-12.9)/million person-years. Incidence in children (aged