Dissemin is shutting down on January 1st, 2025

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Public Library of Science, PLoS Medicine, 11(13), p. e1002179, 2016

DOI: 10.1371/journal.pmed.1002179

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Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis.

Journal article published in 2016 by La Lotta ORCID, Ra Scott, Sj Sharp ORCID, Stephen Burgess ORCID, Jian’an Luan, Therese Tillin, Af Schmidt ORCID, Fumiaki Imamura ORCID, Id Stewart, Jrb Perry, Luke Marney ORCID, Albert Koulman ORCID, Ed Karoly, Ng Forouhi, Rj Sjögren ORCID and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

$\textbf{BACKGROUND}$: Higher circulating levels of the branched-chain amino acids (BCAAs; i.e., isoleucine, leucine, and valine) are strongly associated with higher type 2 diabetes risk, but it is not known whether this association is causal. We undertook large-scale human genetic analyses to address this question. $\textbf{METHODS AND FINDINGS}$: Genome-wide studies of BCAA levels in 16,596 individuals revealed five genomic regions associated at genome-wide levels of significance (p