Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects

Marshall, Christian R.; Howrigan, Daniel P.; Merico, Daniele; Thiruvahindrapuram, Bhooma; Wu, Wenting; Greer, Douglas S.; Antaki, Danny; Shetty, Aniket; Holmans, Peter A.; Pinto, Dalila; Gujral, Madhusudan; Brandler, William M.; Malhotra, Dheeraj; Wang, Zhouzhi; Fajarado, Karin V. Fuentes; Maile, Michelle S.; Ripke, Stephan; Agartz, Ingrid; Ertalan, Marcelo; Albus, Margot; Alexander, Madeline; Amin, Farooq; Atkins, Joshua; Fuentes Fajarado, Karin V.; Bacanu, Silviu A.; Belliveau, Richard A.; Bergen, Sarah E.; Bevilacqua, Elizabeth; Bigdeli, Tim B.; Black, Donald W.; Bertalan, Marcelo; Bruggeman, Richard; Buccola, Nancy G.; Buckner, Randy L.; Bulik Sullivan, Brendan; Byerley, William; Cahn, Wiepke; Cai, Guiqing; Cairns, Murray J.; Campion, Dominique; Cantor, Rita M.; Carr, Vaughan J.; Carrera, Noa; de Haan, Lieuwe; Catts, Stanley V.; Chambert, Kimberley D.; Cheng, Wei; Cohen, David; Cloninger, C. Robert; Cormican, Paul; Craddock, Nick; Crespo Facorro, Benedicto; Crowley, James J.; Curtis, David; Davidson, Michael; Davis, Kenneth L.; Degenhardt, Franziska; Del Favero, Jurgen; DeLisi, Lynn E.; Dikeos, Dimitris; Dinan, Timothy; Djurovic, Srdjan; Donohoe, Gary; Hoffinann, Per; Drapeau, Elodie; Duan, Jubao; Dudbridge, Frank; Eichhammer, Peter; Eriksson, Johan; Escott Price, Valentina; Essioux, Laurent; Fanous, Ayman H.; Farh, Kai-How; Lonnqvist, Jouko; Farrell, Martilias S.; Frank, Josef; Franke, Lude; Freedman, Robert; Freimer, Nelson B.; Friedman, Joseph I.; Forstner, Andreas J.; Fromer, Menachem; Genovese, Giulio; Georgieva, Lyudmila; Gershon, Elliot S.; Giegling, Ina; Muller Myhsok, Bertram; Giusti Rodriguez, Paola; Godard, Stephanie; Goldstein, Jacqueline I.; Gratten, Jacob; Hamshere, Marian L.; De Haan, L.; Hansen, Mark; Hansen, Thomas; Haroutunian, Vahram; Hartmann, Annette M.; Henskens, Frans A.; Herms, Stefan; Hirschhorn, Joel N.; Hofman, Andrea; Hoffmann, Per; Huang, Hailiang; Ikeda, Masashi; Kähler, Anna K.; Joa, Inge; Kahn, René S.; Kalaydjieva, Luba; Karjalainen, Juha; Kavanagh, David; Keller, Matthew C.; Knowles, James A.; Kelly, Brian J.; Konte, Bettina; Kennedy, James L.; Laurent, Claudine; Kim, Yunjung; Lee, Phil; Lee, S. Hong; Legge, Sophie E.; Lerer, Bernard; Levy, Deborah L.; Liang, Kung-Yee; Lieberman, Jeffrey; Lönnqvist, Jouko; Loughland, Carmel M.; Magnusson, Patrik K. E.; Maher, Brion S.; Maier, Wolfgang; Mallet, Jacques; Mattheisen, Manuel; Mattingsdal, Morten; McCarley, Robert W.; McDonald, Colm; McIntosh, Andrew M.; Meier, Sandra; Meijer, Carin J.; Melle, Ingrid; Mesholam Gately, Raquelle I.; Metspalu, Andres; Michie, Patricia T.; Milani, Lili; Milanova, Vihra; Mokrab, Younes; Morris, Derek W.; Müller-Myhsok, Bertram; Murphy, Kieran C.; Murray, Robin M.; Myin Germeys, Inez; Nenadic, Igor; Kahler, Anna K.; Nertney, Deborah A.; Nestadt, Gerald; Nicodemus, Kristin K.; Nisenbaum, Laura; Nordin, Annelie; O'Callaghan, Eadbhard; O'Dushlaine, Colm; Oh, Sang-Yun; Olincy, Ann; Olsen, Line; O'Neill, F. Anthony; Van Os, Jim; Pantelis, Christos; Papadimitriou, George N.; Parkhomenko, Elena; Pato, Michele T.; Paunio, Tiina; Perkins, Diana O.; Pers, Tune Hannes; Pietilainen, Olli; Pimm, Jonathan; Pocklington, Andrew J.; Powell, John; Price, Alkes; Pulver, Ann E.; Purcell, Shaun M.; Quested, Digby; Rasmussen, Henrik B.; Reichenberg, Abraham; Reimers, Mark A.; Richards, Alexander L.; Roffman, Joshua L.; Roussos, Panos; Ruderfer, Douglas M.; Salomaa, Veikko; Sanders, Alan R.; Savitz, Adam; Schall, Ulrich; Soderman, Erik; Schulze, Thomas G.; Schwab, Sibylle G.; Scolnick, Edward M.; Scott, Rodney J.; Seidman, Larry J.; Shi, Jianxin; Silverman, Jeremy M.; Smoller, Jordan W.; Söderman, Erik; Spencer, Chris C. A.; Stahl, Eli A.; Strengman, Eric; Strohmaier, Jana; Stroup, T. Scott; Suvisaari, Jaana; Svrakic, Dragan M.; Szatkiewicz, Jin P.; Thirumalai, Srinivas; Tooney, Paul A.; Veijola, Juha; Visscher, Peter M.; Waddington, John; Walsh, Dermot; Webb, Bradley T.; Weiser, Mark; Wildenauer, Dieter B.; Williams, Nigel M.; Williams, Stephanie; Witt, Stephanie H.; Wolen, Aaron R.; Wormley, Brandon K.; Wray, Naomi R.; Wu, Jing Qin; Zai, Clement C.; Adolfsson, Rolf; Andreassen, Ole A.; Blackwood, Douglas H. R.; Bramon, Elvira; Buxbaum, Joseph D.; Cichon, Sven; Collier, David A.; Corvin, Aiden; Daly, Mark J.; Darvasi, Ariel; Domenici, Enrico; Esko, Tõnu; Gejman, Pablo V.; Gill, Michael; Gurling, Hugh; Hultman, Christina M.; Iwata, Nakao; Jablensky, Assen V.; Jonsson, Erik G.; Kendler, Kenneth S.; Kirov, George; Knight, Jo; Levinson, Douglas F.; Li, Qingqin S.; McCarroll, Steven A.; McQuillin, Andrew; Moran, Jennifer L.; Mowry, Bryan J.; Nothen, Markus M.; Ophoff, Roel A.; Owen, Michael J.; Palotie, Aarno; Pato, Carlos N.; Petryshen, Tracey L.; Posthuma, Danielle; Rietschel, Marcella; Riley, Brien P.; Rujescu, Dan; Sklar, Pamela; St Clair, David; Walters, James T. R.; Werge, Thomas; Sullivan, Patrick F.; O'Donovan, Michael C.; Scherer, Stephen W.; Siillivan, Patrick F.; Neale, Benjamin M.; Sebat, Jonathan; Cnv, and Schizophrenia Working Groups of the Psychiatric Genomics

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Dalila Pinto
Marshall et al., 2016

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Nature Research, Nature Genetics, 1(49), p. 27-35, 2016

DOI: 10.1038/ng.3725

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@article{Marshall2016,
  abstract = {Copy number variants (CNVs) have been strongly implicated in the genetic etiology of schizophrenia (SCZ). However, genome-wide investigation of the contribution of CNV to risk has been hampered by limited sample sizes. We sought to address this obstacle by applying a centralized analysis pipeline to a SCZ cohort of 21,094 cases and 20,227 controls. A global enrichment of CNV burden was observed in cases (odds ratio (OR) = 1.11, P = 5.7 × 10(-15)), which persisted after excluding loci implicated in previous studies (OR = 1.07, P = 1.7 × 10(-6)). CNV burden was enriched for genes associated with synaptic function (OR = 1.68, P = 2.8 × 10(-11)) and neurobehavioral phenotypes in mouse (OR = 1.18, P = 7.3 × 10(-5)). Genome-wide significant evidence was obtained for eight loci, including 1q21.1, 2p16.3 (NRXN1), 3q29, 7q11.2, 15q13.3, distal 16p11.2, proximal 16p11.2 and 22q11.2. Suggestive support was found for eight additional candidate susceptibility and protective loci, which consisted predominantly of CNVs mediated by nonallelic homologous recombination.},
  author = {Marshall, Christian R. and Howrigan, Daniel P. and Merico, Daniele and Thiruvahindrapuram, Bhooma and Wu, Wenting and Greer, Douglas S. and Antaki, Danny and Shetty, Aniket and Holmans, Peter A. and Pinto, Dalila and Gujral, Madhusudan and Brandler, William M. and Malhotra, Dheeraj and Wang, Zhouzhi and Fajarado, Karin V. Fuentes and Maile, Michelle S. and Ripke, Stephan and Agartz, Ingrid and Ertalan, Marcelo and Albus, Margot and Alexander, Madeline and Amin, Farooq and Atkins, Joshua and Fuentes Fajarado, Karin V. and Bacanu, Silviu A. and Belliveau, Richard A. and Bergen, Sarah E. and Bevilacqua, Elizabeth and Bigdeli, Tim B. and Black, Donald W. and Bertalan, Marcelo and Bruggeman, Richard and Buccola, Nancy G. and Buckner, Randy L. and Bulik Sullivan, Brendan and Byerley, William and Cahn, Wiepke and Cai, Guiqing and Cairns, Murray J. and Campion, Dominique and Cantor, Rita M. and Carr, Vaughan J. and Carrera, Noa and de Haan, Lieuwe and Catts, Stanley V. and Chambert, Kimberley D. and Cheng, Wei and Cohen, David and Cloninger, C. Robert and Cormican, Paul and Craddock, Nick and Crespo Facorro, Benedicto and Crowley, James J. and Curtis, David and Davidson, Michael and Davis, Kenneth L. and Degenhardt, Franziska and Del Favero, Jurgen and DeLisi, Lynn E. and Dikeos, Dimitris and Dinan, Timothy and Djurovic, Srdjan and Donohoe, Gary and Hoffinann, Per and Drapeau, Elodie and Duan, Jubao and Dudbridge, Frank and Eichhammer, Peter and Eriksson, Johan and Escott Price, Valentina and Essioux, Laurent and Fanous, Ayman H. and Farh, Kai-How and Lonnqvist, Jouko and Farrell, Martilias S. and Frank, Josef and Franke, Lude and Freedman, Robert and Freimer, Nelson B. and Friedman, Joseph I. and Forstner, Andreas J. and Fromer, Menachem and Genovese, Giulio and Georgieva, Lyudmila and Gershon, Elliot S. and Giegling, Ina and Muller Myhsok, Bertram and Giusti Rodriguez, Paola and Godard, Stephanie and Goldstein, Jacqueline I. and Gratten, Jacob and Hamshere, Marian L. and De Haan, L. and Hansen, Mark and Hansen, Thomas and Haroutunian, Vahram and Hartmann, Annette M. and Henskens, Frans A. and Herms, Stefan and Hirschhorn, Joel N. and Hofman, Andrea and Hoffmann, Per and Huang, Hailiang and Ikeda, Masashi and Kähler, Anna K. and Joa, Inge and Kahn, René S. and Kalaydjieva, Luba and Karjalainen, Juha and Kavanagh, David and Keller, Matthew C. and Knowles, James A. and Kelly, Brian J. and Konte, Bettina and Kennedy, James L. and Laurent, Claudine and Kim, Yunjung and Lee, Phil and Lee, S. Hong and Legge, Sophie E. and Lerer, Bernard and Levy, Deborah L. and Liang, Kung-Yee and Lieberman, Jeffrey and Lönnqvist, Jouko and Loughland, Carmel M. and Magnusson, Patrik K. E. and Maher, Brion S. and Maier, Wolfgang and Mallet, Jacques and Mattheisen, Manuel and Mattingsdal, Morten and McCarley, Robert W. and McDonald, Colm and McIntosh, Andrew M. and Meier, Sandra and Meijer, Carin J. and Melle, Ingrid and Mesholam Gately, Raquelle I. and Metspalu, Andres and Michie, Patricia T. and Milani, Lili and Milanova, Vihra and Mokrab, Younes and Morris, Derek W. and Müller-Myhsok, Bertram and Murphy, Kieran C. and Murray, Robin M. and Myin Germeys, Inez and Nenadic, Igor and Kahler, Anna K. and Nertney, Deborah A. and Nestadt, Gerald and Nicodemus, Kristin K. and Nisenbaum, Laura and Nordin, Annelie and O'Callaghan, Eadbhard and O'Dushlaine, Colm and Oh, Sang-Yun and Olincy, Ann and Olsen, Line and O'Neill, F. Anthony and Van Os, Jim and Pantelis, Christos and Papadimitriou, George N. and Parkhomenko, Elena and Pato, Michele T. and Paunio, Tiina and Perkins, Diana O. and Pers, Tune Hannes and Pietilainen, Olli and Pimm, Jonathan and Pocklington, Andrew J. and Powell, John and Price, Alkes and Pulver, Ann E. and Purcell, Shaun M. and Quested, Digby and Rasmussen, Henrik B. and Reichenberg, Abraham and Reimers, Mark A. and Richards, Alexander L. and Roffman, Joshua L. and Roussos, Panos and Ruderfer, Douglas M. and Salomaa, Veikko and Sanders, Alan R. and Savitz, Adam and Schall, Ulrich and Soderman, Erik and Schulze, Thomas G. and Schwab, Sibylle G. and Scolnick, Edward M. and Scott, Rodney J. and Seidman, Larry J. and Shi, Jianxin and Silverman, Jeremy M. and Smoller, Jordan W. and Söderman, Erik and Spencer, Chris C. A. and Stahl, Eli A. and Strengman, Eric and Strohmaier, Jana and Stroup, T. Scott and Suvisaari, Jaana and Svrakic, Dragan M. and Szatkiewicz, Jin P. and Thirumalai, Srinivas and Tooney, Paul A. and Veijola, Juha and Visscher, Peter M. and Waddington, John and Walsh, Dermot and Webb, Bradley T. and Weiser, Mark and Wildenauer, Dieter B. and Williams, Nigel M. and Williams, Stephanie and Witt, Stephanie H. and Wolen, Aaron R. and Wormley, Brandon K. and Wray, Naomi R. and Wu, Jing Qin and Zai, Clement C. and Adolfsson, Rolf and Andreassen, Ole A. and Blackwood, Douglas H. R. and Bramon, Elvira and Buxbaum, Joseph D. and Cichon, Sven and Collier, David A. and Corvin, Aiden and Daly, Mark J. and Darvasi, Ariel and Domenici, Enrico and Esko, Tõnu and Gejman, Pablo V. and Gill, Michael and Gurling, Hugh and Hultman, Christina M. and Iwata, Nakao and Jablensky, Assen V. and Jonsson, Erik G. and Kendler, Kenneth S. and Kirov, George and Knight, Jo and Levinson, Douglas F. and Li, Qingqin S. and McCarroll, Steven A. and McQuillin, Andrew and Moran, Jennifer L. and Mowry, Bryan J. and Nothen, Markus M. and Ophoff, Roel A. and Owen, Michael J. and Palotie, Aarno and Pato, Carlos N. and Petryshen, Tracey L. and Posthuma, Danielle and Rietschel, Marcella and Riley, Brien P. and Rujescu, Dan and Sklar, Pamela and St Clair, David and Walters, James T. R. and Werge, Thomas and Sullivan, Patrick F. and O'Donovan, Michael C. and Scherer, Stephen W. and Siillivan, Patrick F. and Neale, Benjamin M. and Sebat, Jonathan and Cnv, and Schizophrenia Working Groups of the Psychiatric Genomics},
  doi = {10.1038/ng.3725},
  journal = {Nature Genetics},
  month = {jan},
  pages = {27-35},
  title = {Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects},
  url = {http://orbit.dtu.dk/en/publications/contribution-of-copy-number-variants-to-schizophrenia-from-a-genomewide-study-of-41321-subjects(7a27d5f6-733e-44b3-a4e7-1adae4282aa6).html},
  volume = {49},
  year = {2016}
}

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Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects

Journal article published in 2016 by Christian R. Marshall, Daniel P. Howrigan, Daniele Merico, Bhooma Thiruvahindrapuram, Wenting Wu, Douglas S. Greer, Danny Antaki, Aniket Shetty, Peter A. Holmans, Dalila Pinto

, Madhusudan Gujral, William M. Brandler, Dheeraj Malhotra, Zhouzhi Wang, Karin V. Fuentes Fajarado and other authors. Christian R. Marshall, Daniel P. Howrigan, Daniele Merico, Bhooma Thiruvahindrapuram, Wenting Wu, Douglas S. Greer, Danny Antaki, Aniket Shetty, Peter A. Holmans, Dalila Pinto

, Madhusudan Gujral, William M. Brandler, Dheeraj Malhotra, Zhouzhi Wang, Karin V. Fuentes Fajarado, Michelle S. Maile, Stephan Ripke

, Ingrid Agartz, Marcelo Ertalan, Margot Albus, Madeline Alexander, Farooq Amin, Joshua Atkins, Karin V. Fuentes Fajarado, Silviu A. Bacanu, Richard A. Belliveau, Sarah E. Bergen, Elizabeth Bevilacqua, Tim B. Bigdeli, Donald W. Black, Marcelo Bertalan, Richard Bruggeman, Nancy G. Buccola, Randy L. Buckner, Brendan Bulik Sullivan, William Byerley, Wiepke Cahn, Guiqing Cai, Murray J. Cairns, Dominique Campion, Rita M. Cantor, Vaughan J. Carr, Noa Carrera, Lieuwe de Haan, Stanley V. Catts, Kimberley D. Chambert, Wei Cheng, David Cohen, C. Robert Cloninger

, Paul Cormican, Nick Craddock, Benedicto Crespo Facorro, James J. Crowley, David Curtis, Michael Davidson, Kenneth L. Davis, Franziska Degenhardt, Jurgen Del Favero, Lynn E. DeLisi, Dimitris Dikeos, Timothy Dinan

, Srdjan Djurovic, Gary Donohoe, Per Hoffinann, Elodie Drapeau, Jubao Duan, Frank Dudbridge, Peter Eichhammer, Johan Eriksson, Valentina Escott Price, Laurent Essioux, Ayman H. Fanous, Kai-How Farh, Jouko Lonnqvist, Martilias S. Farrell

, Josef Frank

, Lude Franke

, Robert Freedman, Nelson B. Freimer

, Joseph I. Friedman, Andreas J. Forstner, Menachem Fromer, Giulio Genovese, Lyudmila Georgieva, Elliot S. Gershon, Ina Giegling, Bertram Muller Myhsok, Paola Giusti Rodriguez, Stephanie Godard, Jacqueline I. Goldstein, Jacob Gratten, Marian L. Hamshere, L. De Haan, Mark Hansen, Thomas Hansen

, Vahram Haroutunian, Annette M. Hartmann, Frans A. Henskens, Stefan Herms, Joel N. Hirschhorn, Andrea Hofman, Per Hoffmann, Hailiang Huang

, Masashi Ikeda, Anna K. Kähler, Inge Joa, René S. Kahn, Luba Kalaydjieva, Juha Karjalainen, David Kavanagh, Matthew C. Keller, James A. Knowles

, Brian J. Kelly, Bettina Konte

, James L. Kennedy, Claudine Laurent, Yunjung Kim, Phil Lee, S. Hong Lee, Sophie E. Legge, Bernard Lerer, Deborah L. Levy, Kung-Yee Liang, Jeffrey Lieberman, Jouko Lönnqvist, Carmel M. Loughland, Patrik K. E. Magnusson, Brion S. Maher, Wolfgang Maier, Jacques Mallet, Manuel Mattheisen

, Morten Mattingsdal, Robert W. McCarley, Colm McDonald, Andrew M. McIntosh

, Sandra Meier, Carin J. Meijer, Ingrid Melle, Raquelle I. Mesholam Gately, Andres Metspalu, Patricia T. Michie, Lili Milani

, Vihra Milanova, Younes Mokrab, Derek W. Morris, Bertram Müller-Myhsok, Kieran C. Murphy, Robin M. Murray, Inez Myin Germeys, Igor Nenadic, Anna K. Kahler, Deborah A. Nertney, Gerald Nestadt, Kristin K. Nicodemus, Laura Nisenbaum, Annelie Nordin, Eadbhard O'Callaghan, Colm O'Dushlaine, Sang-Yun Oh, Ann Olincy, Line Olsen, F. Anthony O'Neill, Jim Van Os, Christos Pantelis, George N. Papadimitriou, Elena Parkhomenko, Michele T. Pato, Tiina Paunio, Diana O. Perkins, Tune Hannes Pers, Olli Pietilainen, Jonathan Pimm, Andrew J. Pocklington, John Powell, Alkes Price, Ann E. Pulver, Shaun M. Purcell, Digby Quested, Henrik B. Rasmussen, Abraham Reichenberg, Mark A. Reimers, Alexander L. Richards, Joshua L. Roffman, Panos Roussos, Douglas M. Ruderfer, Veikko Salomaa, Alan R. Sanders, Adam Savitz, Ulrich Schall

, Erik Soderman, Thomas G. Schulze, Sibylle G. Schwab, Edward M. Scolnick, Rodney J. Scott, Larry J. Seidman, Jianxin Shi, Jeremy M. Silverman, Jordan W. Smoller, Erik Söderman, Chris C. A. Spencer, Eli A. Stahl, Eric Strengman, Jana Strohmaier, T. Scott Stroup, Jaana Suvisaari, Dragan M. Svrakic, Jin P. Szatkiewicz, Srinivas Thirumalai, Paul A. Tooney, Juha Veijola, Peter M. Visscher, John Waddington, Dermot Walsh, Bradley T. Webb, Mark Weiser, Dieter B. Wildenauer, Nigel M. Williams, Stephanie Williams, Stephanie H. Witt, Aaron R. Wolen, Brandon K. Wormley, Naomi R. Wray, Jing Qin Wu

, Clement C. Zai

, Rolf Adolfsson, Ole A. Andreassen, Douglas H. R. Blackwood, Elvira Bramon, Joseph D. Buxbaum, Sven Cichon, David A. Collier, Aiden Corvin, Mark J. Daly, Ariel Darvasi, Enrico Domenici, Tõnu Esko, Pablo V. Gejman, Michael Gill, Hugh Gurling, Christina M. Hultman, Nakao Iwata, Assen V. Jablensky, Erik G. Jonsson, Kenneth S. Kendler, George Kirov, Jo Knight, Douglas F. Levinson, Qingqin S. Li, Steven A. McCarroll, Andrew McQuillin, Jennifer L. Moran, Bryan J. Mowry, Markus M. Nothen, Roel A. Ophoff, Michael J. Owen, Aarno Palotie, Carlos N. Pato, Tracey L. Petryshen, Danielle Posthuma, Marcella Rietschel, Brien P. Riley, Dan Rujescu, Pamela Sklar, David St Clair, James T. R. Walters, Thomas Werge, Patrick F. Sullivan, Michael C. O'Donovan, Stephen W. Scherer, Patrick F. Siillivan, Benjamin M. Neale, Jonathan Sebat

, and Schizophrenia Working Groups of the Psychiatric Genomics Cnv

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Abstract

Copy number variants (CNVs) have been strongly implicated in the genetic etiology of schizophrenia (SCZ). However, genome-wide investigation of the contribution of CNV to risk has been hampered by limited sample sizes. We sought to address this obstacle by applying a centralized analysis pipeline to a SCZ cohort of 21,094 cases and 20,227 controls. A global enrichment of CNV burden was observed in cases (odds ratio (OR) = 1.11, P = 5.7 × 10(-15)), which persisted after excluding loci implicated in previous studies (OR = 1.07, P = 1.7 × 10(-6)). CNV burden was enriched for genes associated with synaptic function (OR = 1.68, P = 2.8 × 10(-11)) and neurobehavioral phenotypes in mouse (OR = 1.18, P = 7.3 × 10(-5)). Genome-wide significant evidence was obtained for eight loci, including 1q21.1, 2p16.3 (NRXN1), 3q29, 7q11.2, 15q13.3, distal 16p11.2, proximal 16p11.2 and 22q11.2. Suggestive support was found for eight additional candidate susceptibility and protective loci, which consisted predominantly of CNVs mediated by nonallelic homologous recombination.

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Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects

Abstract