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Published in

Rockefeller University Press, Journal of Experimental Medicine, 1(208), p. 213-213, 2011

DOI: 10.1084/jem.2010242820101229c

Rockefeller University Press, Journal of Experimental Medicine, 13(207), p. 2781-2784, 2010

DOI: 10.1084/jem.20102428

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Induced pluripotent stem cell–derived human platelets: one step closer to the clinic

Journal article published in 2010 by Christos Gekas ORCID, Thomas Graf
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The era of induced pluripotent stem (iPS) cells carries with it the promise of virtually unlimited sources of autologous cells for regenerative medicine. However, efficiently differentiating iPS cells into fully functional mature cell types remains challenging. A new study reporting the formation of fully functional platelets from human iPS (hiPS) cells improves upon recent efforts to generate this enucleated cell type, which remains in high demand for therapeutic transfusions. Notably, their lack of nucleus renders platelets unable to retain the pluripotent or tumorigenic properties of iPS cells.