子宮内膜症の発症・進展における内膜幹細胞の役割とEMT/METの関係の解明 ; Shikyu naimakusho no hatsusho shinten ni okeru naimaku kansaibo no yakuwari to EMT/MET no kankei no kaimei ; The relationship between endometrial stem cells and epithelial-mesenchymal transfer on the development of endometriosis.

升田, 博隆; マスダ, ヒロタカ; Masuda, Hirotaka; 丸山, 哲夫; マルヤマ, テツオ; Maruyama, Tetsuo; 内田, 浩.; ウチダ, ヒロシ; Uchida, Hiroshi

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子宮内膜症の発症・進展における内膜幹細胞の役割とEMT/METの関係の解明 ; Shikyu naimakusho no hatsusho shinten ni okeru naimaku kansaibo no yakuwari to EMT/MET no kankei no kaimei ; The relationship between endometrial stem cells and epithelial-mesenchymal transfer on the development of endometriosis.

Published in 2015 by 博隆升田, ヒロタカマスダ, Hirotaka Masuda, 哲夫丸山, テツオマルヤマ, Tetsuo Maruyama, 浩. 内田, ヒロシウチダ, Hiroshi Uchida

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Abstract

Research team head ; Research team member ; Research team member ; Publisher ; 研究種目 : 基盤研究(C)(一般) 研究期間 : 2013～2015 課題番号 : 25462574 研究分野 : 生殖内分泌 ; ヒト子宮内膜幹細胞候補であるSide Population(SP)細胞, CD146+PDGFRβ+細胞, W5C5細胞はそれぞれ異なる細胞集団であるが, 一部の細胞は重複していることが判明した。子宮内膜症の特徴である浸潤能に注目し, 子宮内膜細胞と子宮内膜SP細胞の遊走性をin vitroで確認した。また, その遊走性はEMT阻害薬により抑えられることをin vitroで明らにした。現在In vivoにおけるEMT阻害剤の浸潤能抑制効果を確認中である。 Flow cytometry analysis revealed that endometrial side population (SP) cells, CD146+PDGFRβ+ cells and W5C5+ cells were different populations, but these populations overlapped partially. The migration activity of endometrial cells and endometrial SP cells was demonstrated, and the activity was suppressed by an epithelial-mesenchymal transfer inhibitor. We are trying to show this inhibitory effect in vivo using our mouse model.