The venom proteome of the poorly studied desert coral snake Micrurus tschudii tschudii was unveiled using a venomic approach, which identified ≥38 proteins belonging to only four snake venom protein families. The three-finger toxins (3FTxs) constitute, both in number of isoforms (~30) and total abundance (93.6% of the venom proteome), the major protein family of the desert coral snake venom. Phospholipases A 2 (PLA 2 s; seven isoforms, 4.1% of the venom proteome), 1–3 Kunitz-type proteins (1.6%), and 1–2 l -amino acid oxidases (LAO, 0.7%) complete the toxin arsenal of M. t. tschudii . Our results add to the growing evidence that the occurrence of two divergent venom phenotypes, i.e. , 3FTx- and PLA 2 -predominant venom proteomes, may constitute a general trend across the cladogenesis of Micrurus . The occurrence of a similar pattern of venom phenotypic variability among true sea snake (Hydrophiinae) venoms suggests that the 3FTx/PLA 2 dichotomy may be widely distributed among Elapidae venoms.