Repeat shipboard and multi-year moored observations obtained in the oxygen minimum zone (OMZ) of the eastern tropical North Atlantic (ETNA) were used to study the decadal change in oxygen for the period 2006–2015. At the depth of the deep oxycline (200–400 m), oxygen decreased with a rate of −6.2 ± 3.8 μmol kg −1 decade −1 , while below the OMZ core (400–1,000 m) oxygen increased by 4.1 ± 1.7 μmol kg −1 decade −1 on average. The inclusion of these decadal oxygen trends in the recently estimated oxygen budget for the ETNA OMZ showed a weakened ventilation of the upper 400 m, whereas the ventilation strengthened homogeneously over depth below 400 m. This resulted in a shoaling of the ETNA OMZ of −0.03 ± 0.02 kg m −3 decade −1 in density space, which was only partly compensated by a deepening of isopycnal surfaces, thus pointing to a shoaling of the OMZ in depth space as well. Shipboard, float and satellite observations of velocity and hydrography indicate different regional as well as remote changes in the circulation pattern to be responsible for the change in the ventilation of the ETNA. The reduced ventilation in the upper 400 m may have been induced by a southward shift of the wind-driven circulation or by a change of the composition of South Atlantic Central Water. There are hints that below 400 m, latitudinally alternating zonal jets have strengthened, thus contributing to the increased ventilation. Nevertheless, temporal changes in isopycnal eddy supply or diapycnal supply (diapycnal mixing as well as diapycnal advection) cannot be excluded in having contributed to the observed oxygen change.