Underground mining activities and rainfall have potential important influence on the initiation and reactivation of the slope deformations, especially on the steep rock slope. In this paper, using the discrete element method (UDEC), numerical simulation was carried out to investigate deformation features and the failure mechanism of the steep rock slope under mining activities and rainfall. A steep rock slope numerical model was created based on a case study at the Wulong area in Chongqing city, China. Mechanical parameters of the rock mass have been determined by situ measurements and laboratory measurements. A preliminary site monitoring system has been realized, aiming at getting structure movements and stresses of unstable rock masses at the most significant discontinuities. According to the numerical model calibrated based on the monitoring data, four types of operation conditions are designed to reveal the effect of mining excavation and extreme rainfall on the deformation of the steep rock slope.