Older institutionalized individuals with reduced residual abilities are going to growth in number in the next years. Monitoring the daily energy expenditure may allow a correct dietary intake and an effective physical activity program, thus improving their life quality. Wearable multisensors (WMS) have been developed to estimate energy expenditure (EE), but, if not calibrated, their accuracy may become questionable. This study was aimed at evaluating WMS accuracy in EE estimation in institutionalized elderly people where individual calibration is difficult to perform. Methods: Twenty-three participants (age 48 ± 27 years; body mass 66.6 ± 12.7 kg; stature 1.69 ± 0.11 m; mean ± SD) were divided in young (YNG, 60 years; n = 7) individuals. EE at two different exercise intensities during cycling with the upper (UA) or lower limbs (LL) and walking was measured by indirect calorimetry (IC) and estimated by WMS. Results: Estimated EE was always significantly lower than in IC in YNG and AD (P