Published in
Springer, Pediatric Nephrology, 5(32), p. 879-884, 2016
DOI: 10.1007/s00467-016-3571-6
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Hypomagnesemia and increased risk of New Onset Diabetes Mellitus after Transplantation in pediatric renal transplant recipients
,
Sheila Boyle,
Detlef Bockenhauer,
Adrian Carroll,
Stephen D. Marks
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Abstract
Background: New onset diabetes after transplantation (NODAT) is a significant co-morbidity following kidney transplantation. Lower post-transplant serum magnesium levels have been found to be an independent risk factor for NODAT in adult kidney transplant recipients. / Methods: We undertook a retrospective analysis of risk factors for NODAT in pediatric renal transplant recipients at our institution with the aim of determining if hypomagnesemia confers a significant risk of developing NODAT in children. / Results: One hundred and seventy three children with median age at transplantation 7.0 (range: 1.3 – 17.5) years were included. Hypomagnesemia was a significant independent risk factor for NODAT (p = 0.01). High trough tacrolimus levels were also independently associated with NODAT (p