Published in
Oxford University Press (OUP), SLEEP, 1(40)
DOI: 10.1093/sleep/zsw011
Links
- ORCID
- ORCID
- ORCID
- ORCID
- ORCID
- Oxford University Press (OUP) | PDF
- [discovery.ucl.ac.uk]
- [helda.helsinki.fi] | PDF
- [erepo.uef.fi] | PDF
- [discovery.ucl.ac.uk] | PDF
- [europepmc.org] | PDF
Tools
Common genetic variation near melatonin receptor 1A gene linked to job-related exhaustion in shift workers.
,
Jukka Alasaari,
Sampsa Puttonen ,
Mikko Härmä,
Katriina Viitasalo,
Alexandra Lahtinen ,
Jaana Lindström ,
Auli Toivola,
Raimo Sulkava,
Mika Kivimäki,
Jussi Vahtera ,
Timo Partonen,
Kaisa Silander,
Tarja Porkka-Heiskanen
and other authors.
Full text: Download
Abstract
STUDY OBJECTIVES: Tolerance to shift work varies; only some shift workers suffer from disturbed sleep, fatigue, and job-related exhaustion. Our aim was to explore molecular genetic risk factors for intolerance to shift work. METHODS: We assessed intolerance to shift work with job-related exhaustion symptoms in shift workers using the emotional exhaustion subscale of the Maslach Burnout Inventory - General Survey, and carried out a genome-wide association study (GWAS) using Illumina's Human610-Quad BeadChip (n = 176). The most significant findings were further studied in three groups of Finnish shift workers (n = 577). We assessed methylation in blood cells with the Illumina HumanMethylation450K, and examined gene expression levels in the publicly available eGWAS Mayo data. RESULTS: The second strongest signal identified in the GWAS (P = 2.3x10E-6) was replicated in two of the replication studies with P