The growing use of commercial unmanned aerial vehicles (UAV) and the need to adjust N fertilization rates in maize (Zea mays L.) currently constitute a key research issue. In this study, different multispectral vegetation indices (green-band and red-band based indices), SPAD and crop height (derived from a multispectral compact camera mounted on a UAV) were analysed to predict grain yield and determine whether an additional sidedress application of N fertilizer was required just before flowering. Seven different inorganic N rates (0, 100, 150, 200, 250, 300, 400 kg·N·ha−1), two different pig slurry manure rates (Ps) (150 or 250 kg·N·ha−1) and four different inorganic-organic N combinations (N100Ps150, N100Ps250, N200Ps150, N200Ps250) were applied to maize experimental plots. The spectral index that best explained final grain yield for the N treatments was the Wide Dynamic Range Vegetation Index (WDRVI). It identified a key threshold above/below 250–300 kg·N·ha−1. WDRVI, NDVI and crop height showed no significant response to extra N application at the economic optimum rate of fertilization (239.8 kg·N·ha−1), for which a grain yield of 16.12 Mg·ha−1 was obtained. This demonstrates their potential as yield predictors at V12 stage. Finally, a ranking of different vegetation indices and crop height is proposed to overcome the uncertainty associated with basing decisions on a single index. ; This work was funded by the Spanish Ministry of Science and Innovation (Project AGL2012-35122). The authors also would like to thank the IRTA Research Station (Gimenells, Lleida) for allowing the research to take place, the GIS & Remote Sensing Laboratory of the University of Lleida for the facilities to carry out the image processing and analysis, and the University of Lleida for the PhD scholarship of Ángel Maresma.