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MDPI, International Journal of Molecular Sciences, 12(17), p. 2082, 2016

DOI: 10.3390/ijms17122082

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Pathophysiology of Non Alcoholic Fatty Liver Disease

Journal article published in 2016 by Salvatore Petta, Amalia Gastaldelli ORCID, Eleni Rebelos, Elisabetta Bugianesi, Piergiorgio Messa, Luca Miele, Gianluca Svegliati-Baroni, Luca Valenti, Ferruccio Bonino
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The physiopathology of fatty liver and metabolic syndrome are influenced by diet, life style and inflammation, which have a major impact on the severity of the clinicopathologic outcome of non-alcoholic fatty liver disease. A short comprehensive review is provided on current knowledge of the pathophysiological interplay among major circulating effectors/mediators of fatty liver, such as circulating lipids, mediators released by adipose, muscle and liver tissues and pancreatic and gut hormones in relation to diet, exercise and inflammation.