So why make your work available as preprints? There are perceived positives and negatives to disclosing scientific work in the form of a preprint, explored here in the form of 10 Simple Rules. These rules, if they pass review, will appear as part of the PLOS Computational Biology Ten Simple Rules Collection. The rules cover such issues as reward, incentives, speed of dissemination, quality, scooping, and record of priority. You cannot have an article describing preprints, without itself being a preprint!!