We construct an intriguing bijection between $021$-avoiding inversion sequences and $(2413,4213)$-avoiding permutations, which proves a sextuple equidistribution involving double Eulerian statistics. Two interesting applications of this result are also presented. Moreover, this result inspires us to characterize all permutation classes that avoid two patterns of length $4$ whose descent polynomial equals that of separable permutations. ; Comment: 18 pages, 5 figures, update two typos