American Chemical Society, Organic Letters, 16(16), p. 4268-4271, 2014
DOI: 10.1021/ol501967c
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Efficient copper - catalyzed trifluoromethylation of aromatic iodides was achieved with TMSCF 3 in the presence of trimethoxyborane. The Lewis acid was used to anchor the in situ generated trifluoromethyl anion and suppress its rapid decomp os i- tion. Broad applicability of the new trifluoromethylating reaction was demonstrated in the functionali zation of different aromatic and heteroaro matic iodides.