Dissemin is shutting down on January 1st, 2025

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Wiley, European Journal of Clinical Investigation, 10(44), p. 1010-1023, 2014

DOI: 10.1111/eci.12319

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Research update for articles published in EJCI in 2012

Journal article published in 2014 by Dullaart Rp, Max Plischcke, Robin Pf F. Dullaart, Nasser M. Al-Daghri, Al Daghri Nm, Messoud Ashina, Alberto Bouzas-Mosquera, Brunetti Nd, Natale Daniele Brunetti ORCID, Christa Buechler, Chen Hs, Harn-Shen Chen, Juan J. Corrales, Massimo D'Archivio, Corrales Jj and other authors.
This paper is available in a repository.
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Abstract

Phospholipase Cγ2 (PLCγ2) is a critical regulator of osteoclast differentiation and basal bone resorption, which was demonstrated by Kertész et al. in agreement with previous reports(1). The role of the PLCγ isoenzyme in bone resorption and in adhesion receptor signalling of osteoclasts was further emphasized in a recent review(2) reinforcing the statements made by Kertész et al.,(1). Moreover, Dr. Faccio's group provided genetic evidence that targeting PLCγ2 can suppress inflammatory osteolysis(3). This article is protected by copyright. All rights reserved.