Purpose: Since non-provocative dive profiles are no guarantor of protection against decompression sickness, novel means including pre-dive preconditioning interventions, are proposed for its prevention. This study investigated and compared the effect of pre-dive oxygenation, pre-dive whole body vibration or a combination of both on post-dive bubble formation. Methods: 6 healthy volunteers performed 6 no-decompression dives each, to a depth of 33 mfw for 20 minutes (3 control dives without preconditioning and 1 of each preconditioning protocol) with a minimum interval of 1 week between each dive. Post-dive bubbles were counted in the precordium by two-dimensional echocardiography, 30 and 90 minutes after the dive, with and without knee flexing. Each diver served as his own control.Results: Vascular gas emboli (VGE) were systematically observed before and after knee flexing at each post-dive measurement. Compared to the control dives, we observed a decrease in VGE count of 23.8±7.4% after oxygen breathing (p