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BioMed Central, BMC Musculoskeletal Disorders, 1(17), 2016

DOI: 10.1186/s12891-016-1148-y

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Visual detection of cortical breaks in hand joints: reliability and validity of high-resolution peripheral quantitative CT compared to microCT

Journal article published in 2016 by A. Scharmga ORCID, M. Peters, A. van Tubergen ORCID, J. van den Bergh, J. de Jong, D. Loeffen, B. van Rietbergen, R. Weijers, P. Geusens
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract Background To study the reliability and validity of high-resolution peripheral quantitative CT (HR-pQCT) with microCT (μCT) as gold standard in the visual detection of cortical breaks in metacarpophalangeal (MCP) and proximal interphalangeal (PIP) joints. Methods Ten cadaveric fingers (10 MCP and 9 PIP joints) were imaged by HR-pQCT and μCT and visually analyzed by two independent readers. Intra- and interreader reliability were evaluated for the presence (yes/no, kappa statistics) and the total number (intraclass correlation coefficient, ICC) of cortical breaks. Sensitivity, specificity, positive and negative predictive value (PPV respectively NPV) of HR-pQCT in detecting cortical breaks were calculated. Results With HR-pQCT, mean 149 cortical breaks were identified and with μCT mean 129 (p