Additional file 12: Figure S7. of Heterogeneity of CD34 and CD38 expression in acute B lymphoblastic leukemia cells is reversible and not hierarchically organized

Jiang, Zhiwu; Deng, Manman; Wei, Xinru; Ye, Wei; Xiao, Yiren; Lin, Simiao; Wang, Suna; Li, Baiheng; Liu, Xin; Zhang, Gong; Lai, Peilong; Weng, Jianyu; Wu, Donghai; Chen, Haijia; Wei, Wei; Yuguo,; Li, Yangqiu; Liu, Pentao; Du, Xin; Pei, Duanqing; Yao, Yao; Xu, Bing; Li, Peng

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Additional file 12: Figure S7. of Heterogeneity of CD34 and CD38 expression in acute B lymphoblastic leukemia cells is reversible and not hierarchically organized

Published in 2016 by Zhiwu Jiang, Manman Deng, Xinru Wei, Wei Ye, Yiren Xiao, Simiao Lin, Suna Wang, Baiheng Li, Xin Liu, Gong Zhang, Peilong Lai, Jianyu Weng, Donghai Wu, Haijia Chen, Wei Wei and other authors.

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Abstract

Leukemic cellsâ SNPs are conserved in ex vivo. (A) Whole exome sequencing of the leukemia in xenografts (before culture, B. C.), after culture (A. C.) and after transplantation (A. T.) revealed the presence of genome mutations. Similar rates of nonsynonymous and synonymous single nucleotide variants (SNVs) within the leukemia of patient #1 and patient #7. (B, C) Venn diagram present B-ALL cells from co-culture and B-ALL cells from xenografts share similar nonsynonymous SNP profiles. (JPG 1513 kb)