Abstract Background Increasing the weekly frequency of hemodialysis sessions has positive effects, on the control of several biological data of patients. However, knowledge about Daily HemoDialysis (DHD) practices is limited in France. The aim of the present study was to describe the characteristics and treatment trajectories of all French patients undergoing DHD. Methods All patients older than 18 years who started DHD between 2003 and 2012 in France were included and followed until December 31, 2013. The patients’ demographic and clinical characteristics and treatment modalities were extracted from the French Renal Epidemiological and Information Network (REIN) registry. Results During the inclusion period, 753 patients started DHD in France. Based on their median age (64 years), patients were classified in two groups: “old” group (≥64 years) and “young” group (