Behavioral studies suggested that newborns can show communicative competences and that they can visually recognize a face previously seen since from the birth. The neurobiological evidence of this ability was demonstrated by four-months of life, and there is a considerable scepticism about the neurobiological maturation necessary for this ability before three-months of life. 23 newborns (11 newborns M ¼ 4.7; DS ¼ 3.3 hours old were included in the analyses) performed the following visual procedure: a presentation of a face for 60s (Target); then 50 trials of Target, 50 trials of Unknown faces and 50 trials of a neutral stimulus, each trial lasted 2 s. Event-related potential (ERP) analysis showed a difference amplitude in response to Target vs. Unknown on left occipitotemporal montage from 300 ms and a shorter latency in response to Target compared to Unknown. Time-frequency analysis showed a higher Beta1-band activity in response to Target compared to Unknown at 500–600 ms on occipital-temporal. Connectivity results showed higher implication in fusiform gyrus with known face. Findings suggest that the newborns have the ability to discriminate a familiar face from a stranger since from the birth; this result has a relevant clinical implication for the possibility to find early neural marker for psychopathology as the autism.