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Wiley, Journal of Magnetic Resonance Imaging, 3(27), p. 469-475, 2008

DOI: 10.1002/jmri.21246

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Serial postmortem relaxometry in the normal rat brain and following stroke

Journal article published in 2008 by Andrew J. Fagan ORCID, Jim M. Mullin, Lindsay Gallagher, Donald M. Hadley, I. Mhairi Macrae, Barrie Condon
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Purpose: Investigation of MRI for non-invasive autopsy via measurements of serial changes in relaxation parameters of the rat brain during the post-mortem interval. Materials and Methods: Post-mortem relaxometry measurements were performed before and hourly after death for 24 hours on five control rats and five rats which underwent middle cerebral artery occlusion. Analyses were performed on representative regions of grey, white, and mixed grey/white matter structures. Results: Significant decreases in both T1 and T2 values were measured in all areas in the control group within 24 hours of death. In the stroke animals, T2 differences between normal and ischaemic striatal tissue decreased by 114% (p