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Hindawi, Journal of Biomedicine and Biotechnology, (2011), p. 1-8, 2011

DOI: 10.1155/2011/230481

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Cytogenetic Instability in Childhood Acute Lymphoblastic Leukemia Survivors

Journal article published in 2011 by María Sol Brassesco ORCID, Danilo Jordão Xavier, Marjori Leiva Camparoto, Ana Paula Montaldi, Paulo Roberto D'Auria Vieira de Godoy, Carlos Alberto Scrideli ORCID, Luiz Gonzaga Tone ORCID, Elza Tiemi Sakamoto-Hojo
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Contemporary anticancer therapies have largely improved the outcome for children with cancer, especially for Acute Lymphoblastic Leukemia (ALL). Actually, between 78% and 85% of patients achieve complete remission and are alive after 5 years of therapy completion. However, as cure rates increase, new concerns about the late effects of genotoxic treatment emerge, being the risk of developing secondary neoplasias, the most serious life-threatening rising problem. In the present paper, we describe and review the cytogenetic findings in peripheral lymphocytes from ALL survivors, and discuss aspects associated to the occurrence of increased chromosome rearrangements in this growing cohort.