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BioMed Central, Genome Biology, 10(10), p. R105

DOI: 10.1186/gb-2009-10-10-r105

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MethMarker: user-friendly design and optimization of gene-specific DNA methylation assays

Journal article published in 2009 by Peter Schüffler ORCID, Thomas Mikeska, Andreas Waha, Thomas Lengauer, Christoph Bock ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract DNA methylation is a key mechanism of epigenetic regulation that is frequently altered in diseases such as cancer. To confirm the biological or clinical relevance of such changes, gene-specific DNA methylation changes need to be validated in multiple samples. We have developed the MethMarker http://methmarker.mpi-inf.mpg.de/ software to help design robust and cost-efficient DNA methylation assays for six widely used methods. Furthermore, MethMarker implements a bioinformatic workflow for transforming disease-specific differentially methylated genomic regions into robust clinical biomarkers.