Published in

American Society for Microbiology, Journal of Virology, 21(81), p. 12086-12090, 2007

DOI: 10.1128/jvi.00800-07

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Identification of an arsenic sensitive block to primate lentiviral infection of human dendritic cells

Journal article published in 2007 by Marjorie Pion ORCID, Rs S. Stalder, Rafael Correa, Bastien Mangeat, Vincent Piguet, Greg J. Towers ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT Dendritic cells are central to the early events of human immunodeficiency virus type 1 (HIV-1) transmission, but HIV-1 infects dendritic cells inefficiently in vitro compared to activated CD4 + T cells. There is a strong postentry restriction of HIV-1 infection in dendritic cells, partly mediated by the cellular restriction factor APOBEC3G. Here, we reveal that arsenic trioxide markedly increases HIV infection of immature and mature dendritic cells as well as blood-derived myeloid dendritic cells in an APOBEC3G- and TRIM5α-independent way. Our data suggest the presence of powerful, arsenic-sensitive antiviral activities in primary human immune cells of the dendritic cell lineage.