Links

Tools

Export citation

Search in Google Scholar

Investigation of gene-environment interactions between 47 newly identified breast cancer susceptibility loci and environmental risk factors

Journal article published in 2015 by Roger L. Milne, Anja Rudolph, Julia A. Knight, Milne Rl, Thérèse Truong, Alison M. Dunning, Petra Seibold, Hannah R. Munday, Dieter Flesch-Janys, Celine M. Vachon, Knight Ja, Betul T. Yesilyurt, Ursula Eilber, Sabine Behrens, Jingmei Li and other authors.
This paper was not found in any repository; the policy of its publisher is unknown or unclear.
This paper was not found in any repository; the policy of its publisher is unknown or unclear.

Full text: Unavailable

Question mark in circle
Preprint: policy unknown
Upload
Question mark in circle
Postprint: policy unknown
Upload
Question mark in circle
Published version: policy unknown
Upload

Abstract

A large genotyping project within the Breast Cancer Association Consortium (BCAC) recently identified 41 associations between single nucleotide polymorphisms (SNPs) and overall breast cancer (BC) risk. We investigated whether the effects of these 41 SNPs, as well as six SNPs associated with estrogen receptor (ER) negative BC risk are modified by 13 environmental risk factors for BC. Data from 22 studies participating in BCAC were pooled, comprising up to 26,633 cases and 30,119 controls. Interactions between SNPs and environmental factors were evaluated using an empirical Bayes-type shrinkage estimator. Six SNPs showed interactions with associated p-values (pint)