Elsevier, Stem Cell Research, 3(17), p. 661-664, 2016
DOI: 10.1016/j.scr.2016.11.005
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Peripheral blood mononuclear cells (PBMC) were collected from a patient with clozapine-resistant (also known as “super-refractory”) Schizophrenia. iPSCs were established with a non-integrating Sendai Virus-based reprogramming system. A footprint-free hiPSC line was characterized to express the main endogenous pluripotency markers and a normal karyotype. Cells showed pluripotency competency by giving rise to progeny of differentiated cells belonging to the three germ layers. This hiPSC line represents a valuable tool to obtain mature, pathology-relevant neuronal populations in vitro that are suitable to investigate the molecular background of the schizophrenic disorder and the resultant patients' response to treatments.