Rationale and design of SuPPoRT: a multi-centre randomised controlled trial to compare three treatments: cervical cerclage, cervical pessary and vaginal progesterone, for the prevention of preterm birth in women who develop a short cervix

Hezelgrave, Natasha L.; Watson, Helena A.; Ridout, Alexandra; Diab, Falak; Seed, Paul T.; Chin-Smith, Evonne; Tribe, Rachel M.; Shennan, Andrew H.

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Rationale and design of SuPPoRT: a multi-centre randomised controlled trial to compare three treatments: cervical cerclage, cervical pessary and vaginal progesterone, for the prevention of preterm birth in women who develop a short cervix

Journal article published in 2016 by Natasha L. Hezelgrave, Helena A. Watson, Alexandra Ridout, Falak Diab, Paul T. Seed

, Evonne Chin-Smith, Rachel M. Tribe

, Andrew H. Shennan

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Abstract

Abstract Background Clinically, once a woman has been identified as being at risk of spontaneous preterm birth (sPTB) due to a short cervical length, a decision regarding prophylactic treatment must be made. Three interventions have the potential to improve outcomes: cervical cerclage (stitch), vaginal progesterone and cervical pessary. Each has been shown to have similar benefit in reduction of sPTB, but there have been no randomised control trials (RCTs) to compare them. Methods This open label multi-centre UK RCT trial, will evaluate whether the three interventions are equally efficacious to prevent premature birth in women who develop a short cervix (

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Rationale and design of SuPPoRT: a multi-centre randomised controlled trial to compare three treatments: cervical cerclage, cervical pessary and vaginal progesterone, for the prevention of preterm birth in women who develop a short cervix

Abstract